Positive Transcriptional Elongation Factor B

A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE T CYCLINS and cyclin K. It functions by phosphorylating the carboxy-terminal domain of RNA POLYMERASE II.

Also Known As:

P-TEFb; Positive Transcription Elongation Factor B; tat-Associated Kinase; tat Associated Kinase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Positive Transcriptional Elongation Factor B: 109
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Transcriptional Elongation Factors: 2
      - Positive Transcriptional Elongation Factor B: 109
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Positive Transcriptional Elongation Factor B: 109

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Raymond S Brown Research Topics

Disease

Drug/Important Bio-Agent (IBA)